Gastrointestinal Surgery for Inflammatory Bowel Disease Persistently Lowers Microbiome and Metabolome Diversity

X. Fang, Y. Vázquez-Baeza, E. Elijah, F. Vargas, G. Ackermann, G. Humphrey, R. Lau, K. C. Weldon, J. G. Sanders, M. Panitchpakdi, C. Carpenter, A. K. Jarmusch, J. Neill, A. Miralles, P. Dulai, S. Singh, M. Tsai, A. D. Swafford, L. Smarr, D. L. Boyle, B. O. Palsson, J. T. Chang, P. C. Dorrestein, W. J. Sandborn, R. Inflammatory Bowel Diseases, 27, 603–616 (2021). https://doi.org/10.1093/ibd/izaa262

Abstract

Many studies have investigated the role of the microbiome in inflammatory bowel disease (IBD), but few have focused on surgery specifically or its consequences on the metabolome that may differ by surgery type and require longitudinal sampling. Our objective was to characterize and contrast microbiome and metabolome changes after different surgeries for IBD, including ileocolonic resection and colectomy.

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